New Approaches to Chronic Hepatitis B | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Each hepatitis virus—Hepatitis A, B, C, D, E, and G—poses a distinct scenario to the patient
and clinician alike. Since the discovery of each virus, extensive knowledge regarding …

More than 250 million people are living with chronic hepatitis B despite the availability of
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …

Objective Hepatitis B virus (HBV)-specific T cells are main effector cells in the control of HBV
infection and hepatitis B surface antigen (HBsAg) is suggested to be a critical factor in the …

Simple Summary Infections with Hepatitis B and Hepatitis C viruses are usually
asymptomatic and although some patients undergo resolution of infection, the majority do …

Hepatitis B is the most prevalent viral hepatitis worldwide, affecting approximately one-third
of the world's population. Among HBV factors, the surface protein is the most sensitive …

Chronic hepatitis B virus (HBV) infection is an international health problem with extremely
high mortality and morbidity rates. Although current clinical chronic hepatitis B (CHB) …

Objective Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection
are broadly heterogeneous. Characterisation of their functional impairment may allow to …

Toll‐like receptor 7 (TLR7) agonists modulate broad spectrum immune activity and are
evaluated in the treatment of human diseases, including cancer and chronic viral infection …

Chronic hepatitis B virus (HBV) infection is a major global health burden causing severe
complications like liver cirrhosis or hepatocellular carcinoma. Curative treatment options are …