Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Currently, there are no treatment options available for the deadly contagious disease,
coronavirus disease 2019 (COVID-19). Drug repurposing is a process of identifying new …

There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …

The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

Drugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in
water or in lipid-containing media. The predominantly lipophilic statins (simvastatin …

Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

To characterize the role of the circadian clock in mouse physiology and behavior, we used
RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

It has been known that a considerable number of drugs in clinical use or under development
are water-insoluble drugs with poor bioavailability (BA). The liposomal delivery system has …

Despite widespread use of statins to reduce low-density lipoprotein cholesterol (LDL-C) and
associated atherosclerotic cardiovascular risk, many patients do not achieve sufficient LDL …