Mitochondria as cellular and organismal signaling hubs
Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …
extend far beyond energy production. They are vital in cellular and organismal pathways …
Mechanisms and regulation of protein synthesis in mitochondria
E Kummer, N Ban - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …
process called oxidative phosphorylation. They originate from a bacterial ancestor and …
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
[HTML][HTML] Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I
Oocytes form before birth and remain viable for several decades before fertilization.
Although poor oocyte quality accounts for most female fertility problems, little is known about …
Although poor oocyte quality accounts for most female fertility problems, little is known about …
[HTML][HTML] Pleiotropic effects of mitochondria in aging
Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
Sarcopenia: aging-related loss of muscle mass and function
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …
diminishes quality of life, and can lead to fall-related injuries, which require costly …
[HTML][HTML] Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production,
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …
[PDF][PDF] Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a systematic review and meta‐analysis
F Zhou, J Zhou, W Wang, XJ Zhang, YX Ji… - …, 2019 - Wiley Online Library
With rapid lifestyle transitions, the increasing burden of nonalcoholic fatty liver disease
(NAFLD) in China has emerged as a major public health issue. To obtain a comprehensive …
(NAFLD) in China has emerged as a major public health issue. To obtain a comprehensive …
[HTML][HTML] Mitophagy and quality control mechanisms in mitochondrial maintenance
S Pickles, P Vigié, RJ Youle - Current Biology, 2018 - cell.com
The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …
development as well as throughout life in the response to physiological adaptations and …