Potassium inward rectifier channel Kir2 is an important component of terminal cardiac
repolarization and resting membrane stability. This functionality is part of balanced cardiac …

Microtubules are essential cytoskeletal elements found in all eukaryotic cells. The structure
and composition of microtubules regulate their function, and the dynamic remodeling of the …

In a family with inappropriate sinus tachycardia (IST), we identified a mutation (p. V240M) of
the hyperpolarization-activated cyclic nucleotide–gated type 4 (HCN4) channel, which …

Ion channels are transmembrane proteins that conduct specific ions across biological
membranes. Ion channels are present at the onset of many cellular processes, and their …

Oxygen maintains the homeostasis of an organism in a delicate balance in different tissues
and organs. Under hypoxic conditions, hypoxia-inducible factors (HIFs) are specific and …

Protein–protein interactions are essential for normal cellular processes and signaling
events. Defining these interaction networks is therefore crucial for understanding complex …

Titanium dioxide (TiO 2) is an efficient, low-cost, and environmentally friendly photocatalyst
that can be used to degrade organic pollutants and heavy metals. It has capability for …

Rationale: Loss-of-function of the cardiac sodium channel NaV1. 5 causes conduction
slowing and arrhythmias. NaV1. 5 is differentially distributed within subcellular domains of …

Andersen-Tawil syndrome (ATS) is a rare inheritable disease associated with loss-of-
function mutations in KCNJ2, the gene coding the strong inward rectifier potassium channel …

Abstract Cardiac Nav1. 5 and Kir2. 1–2.3 channels generate Na (I Na) and inward rectifier K
(I K1) currents, respectively. The functional I Na and I K1 interplay is reinforced by the …