CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

Trafficking of leukocytes and their local activity profile are of pivotal importance for many
(patho) physiological processes. Fittingly, microenvironments are complex by nature, with …

Galectin-3 (Gal-3) is a β-galactoside-binding protein that influences various cell functions,
including cell adhesion. We focused on the role of Gal-3 as an extracellular ligand mediating …

Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

Melanoma cell adhesion molecule (MCAM, CD146, MUC18) is a heavily glycosylated
transmembrane protein and a marker of melanoma metastasis. It is expressed in advanced …

Human galectin-3 (h Gal-3) is involved in a variety of biological processes and is implicated
in wide range of diseases. As a result, targeting h Gal-3 for clinical applications has become …

Cerebral malaria (CM) is a life-threatening diffuse encephalopathy caused by Plasmodium
falciparum, in which the destruction of the blood–brain barrier (BBB) is the main cause of …

Extra-and intra-cellular activity occurs under the direction of numerous inter-molecular
interactions, and in any tissue or cell, molecules are densely packed, thus promoting those …

Vascular endothelial dysfunction is a major risk factor in the development of renal diseases.
Recent studies pointed out a major interest for the inter-endothelial junction protein CD146 …

Intrinsically disordered regions (IDRs) are common and important functional domains in
many proteins. However, IDRs are difficult to target for drug development due to the lack of …