Many lung disease processes are characterized by structural and functional heterogeneity
that is not directly appreciable with traditional physiological measurements. Experimental …

The spectral parameters of hyperpolarized 129Xe exchanging between airspaces, interstitial
barrier, and red blood cells (RBCs) are sensitive to pulmonary pathophysiology. This study …

To understand the determinants of inhaled aerosol particle distribution and targeting in the
lung, knowledge of regional deposition, lung morphology and regional ventilation, is crucial …

Magnetic resonance (MR) imaging and spectroscopy using dissolved hyperpolarized (HP)
129Xe have expanded the ability to probe lung function regionally and noninvasively. In …

Objectives: Determine the intra-tidal regional gas and blood volume distributions at different
levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration …

Rationale: Intratidal changes in regional lung aeration, as assessed with dynamic four-
dimensional computed tomography (CT; 4DCT), may indicate the processes of recruitment …

Noninvasive imaging of the murine pulmonary vasculature is challenging due to the small
size of the animal, limits of resolution of the imaging technology, terminal nature of the …

More than 50 years ago, John West and colleagues (1) published their landmark study on
the vertical distribution of blood flow in the lung as a result of the interplay between the local …

Mechanical ventilation exposes the lung to mechanical stresses that can exacerbate or
induce injury in patients with respiratory failure, a condition known as Ventilator-Induced …

Chronic respiratory diseases are one of the leading causes of death in the US and a driving
factor in their mortality rate is the presence of comorbid cardiovascular diseases such as …