Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Neurodegenerative diseases are characterized by the presence of cross-β-sheet amyloid
fibrils and a rich mesoscopic polymorphism, requiring noninvasive detection with high …

Amyloid-β (Aβ) oligomers are a cause of neurodegeneration in Alzheimer's disease (AD).
These soluble aggregates of the Aβ peptide have proven difficult to study due to their …

β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three
different alignments of β-hairpins have been observed in the structures of Aβ oligomers or …

Freezing is essential for the stability of biological drug substances and products, particularly
in frozen solution formulations and during the primary drying of lyophilized preparations …

A long-standing challenge in bioinspired materials is to design and synthesize synthetic
materials that mimic the sophisticated structures and functions of natural biomaterials, such …

Primases are crucial enzymes for DNA replication, as they synthesize a short primer
required for initiating DNA replication. We herein present time-resolved nuclear magnetic …

Protein amyloid fibrils are supramolecular homopolymers that play a role in numerous
biological processes and illnesses. The link between type 2 diabetes and insulin-induced …

Understanding the amyloid nucleation mechanism is fundamentally important for the
development of diagnostics and therapeutics of amyloid-related diseases and for the design …

The aggregation of amyloid peptides and proteins into toxic oligomers is a hallmark of
neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease …