Advancements in Cell-Based Therapies for HIV Cure
Y Matsui, Y Miura - Cells, 2023 - mdpi.com
The treatment of human immunodeficiency virus (HIV-1) has evolved since the
establishment of combination antiretroviral therapy (ART) in the 1990s, providing HIV …
establishment of combination antiretroviral therapy (ART) in the 1990s, providing HIV …
Opportunities for CAR-T cell immunotherapy in HIV cure
G Campos-Gonzalez, J Martinez-Picado… - Viruses, 2023 - mdpi.com
Chimeric antigen receptor (CAR) technology is having a huge impact in the blood
malignancy field and is becoming a well-established therapy for many types of leukaemia. In …
malignancy field and is becoming a well-established therapy for many types of leukaemia. In …
Harnessing immune cells to eliminate HIV reservoirs
P Grasberger, AR Sondrini… - Current Opinion in HIV …, 2024 - journals.lww.com
Several studies have shown promise in many preclinical models of disease, including
simian immunodeficiency virus (SIV)/SHIV infection in nonhuman primates and HIV infection …
simian immunodeficiency virus (SIV)/SHIV infection in nonhuman primates and HIV infection …
Stem cell-derived CAR T cells show greater persistence, trafficking, and viral control compared to ex vivo transduced CAR T cells
Adoptive cell therapy (ACT) using T cells expressing chimeric antigen receptors (CARs) is
an area of intense investigation in the treatment of malignancies and chronic viral infections …
an area of intense investigation in the treatment of malignancies and chronic viral infections …
Challenges in HIV-1 latent reservoir and target cell quantification in CAR-T cell and other lentiviral gene modifying HIV cure strategies
AM Buck, TM Deveau, TJ Henrich, AN Deitchman - Viruses, 2023 - mdpi.com
Gene-modification therapies are at the forefront of HIV-1 cure strategies. Chimeric antigen
receptor (CAR)-T cells pose a potential approach to target infected cells during antiretroviral …
receptor (CAR)-T cells pose a potential approach to target infected cells during antiretroviral …
Recent advances using genetic therapies against infectious diseases and for vaccination
The development of prophylatic or therapeutic medicines for infectious diseases is one of
the priorities for health organizations worldwide. Innovative solutions are required to achieve …
the priorities for health organizations worldwide. Innovative solutions are required to achieve …
Efficient ex vivo expansion of conserved element vaccine-specific CD8+ T-cells from SHIV-infected, ART-suppressed nonhuman primates
S Dross, R Venkataraman, S Patel, ML Huang… - Frontiers in …, 2023 - frontiersin.org
HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient
for viral clearance. This is due in part to these cells' recognition of immunodominant but …
for viral clearance. This is due in part to these cells' recognition of immunodominant but …
CAR-T cell therapy: Where are we now, and where are we heading?
JY Wang, L Wang - Blood Science, 2023 - mednexus.org
Chimeric antigen receptor (CAR)-T-cell therapies have exhibited remarkable efficacy in the
treatment of hematologic malignancies, with 9 CAR-T-cell products currently available …
treatment of hematologic malignancies, with 9 CAR-T-cell products currently available …
Strategies to target the central nervous system HIV reservoir
Targeting the CNS remains a potential problem for the currently investigated HIV curing
strategies. In vivo evidence on CNS effectiveness is limited for most of the investigated …
strategies. In vivo evidence on CNS effectiveness is limited for most of the investigated …
Hematopoietic stem cell transplantation and cellular therapy in persons living with HIV
PG Rubinstein, C Galvez… - Current Opinion in …, 2024 - journals.lww.com
Hematopoietic stem cell transplantation and cellular therapy in persons living with HIV Page 1
QCO 370411 CURRENT OPINION Hematopoietic stem cell transplantation and cellular therapy …
QCO 370411 CURRENT OPINION Hematopoietic stem cell transplantation and cellular therapy …