Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …

The third generation β-blockers possess important ancillary properties besides inhibiting β-
adrenoceptors. Among them, nebivolol activates nitric oxide synthase (NOS). Nebivolol and …

Objectives: The aim of this study was to determine whether activation of β3-adrenergic
receptor (AR) and downstream signaling of nitric oxide synthase (NOS) isoforms protects the …

Many clinical studies have documented favourable effects (reduced morbidity and mortality)
of beta-adrenoceptor (β-AR) antagonists, such as carvedilol, metoprolol, propranolol …

Abstract Purpose of Review Current guidelines for the management of arterial hypertension
endorse β-adrenergic receptor blocking agents (beta-blockers, BBs) as being particularly …

The presence of a third β-adrenergic receptor (β3-AR) in the cardiovascular system has
challenged the classical paradigm of sympathetic regulation by β1-and β2-adrenergic …

Objectives: The present study was to assess whether nebivolol could activate β3-adrenergic
receptors (ARs) in the human heart. Background: Nebivolol is a third-generation β-blocker …

The β 1-adrenergic antagonist metoprolol improves cardiac function in animals and patients
with chronic heart failure, isolated mitral regurgitation (MR), and ischemic heart disease …

Background and Purpose Aucubin, the predominant component of Eucommia ulmoides
Oliv., has been shown to have profound effects on oxidative stress. As oxidative stress has …

It is well established that cardiac remodeling plays a pivotal role in the development of heart
failure, a leading cause of death worldwide. Meanwhile, sympathetic hyperactivity is an …