Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major
cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the …

Multidrug resistance is quite common among non-fermenting Gram-negative rods, in
particular among clinically relevant species including Pseudomonas aeruginosa and …

CTX-M β-lactamases are considered a paradigm in the evolution of a resistance
mechanism. Incorporation of different chromosomal bla CTX-M related genes from different …

Pseudomonas aeruginosa is intrinsically resistant to a variety of antimicrobials and can
develop resistance during anti-pseudomonal chemotherapy both of which compromise …

Production of extended-spectrum β-lactamases (ESBLs) is the principal mechanism of
resistance to oxyimino-cephalosporins evolved by members of the family …

Acinetobacter baumannii has emerged as a highly troublesome pathogen for many
institutions globally. As a consequence of its immense ability to acquire or upregulate …

We may soon be facing the end of the “antibiotic era.” The initial and seemingly unstoppable
success of antibiotics, the fruit of human ingenuity, has been countered by an escalation of …

In the past decade CTX-M enzymes have become the most prevalent extended-spectrum β-
lactamases, both in nosocomial and in community settings. The insertion sequences (ISs) …

During the past few decades Acinetobacter baumannii has evolved from being a commensal
dweller of health-care facilities to constitute one of the most annoying pathogens …

CTX-M enzymes, the plasmid-mediated cefotaximases, constitute a rapidly growing family of
extended-spectrum β-lactamases (ESBLs) with significant clinical impact. CTX-Ms are found …