Practical Considerations for Next-Generation Adjuvant Development and Translation
Over the last several years, there has been increased interest from academia and the
pharmaceutical/biotech industry in the development of vaccine adjuvants for new and …
pharmaceutical/biotech industry in the development of vaccine adjuvants for new and …
Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations
B Lee, E Nanishi, O Levy, DJ Dowling - Pharmaceutics, 2023 - mdpi.com
Infection persists as one of the leading global causes of morbidity and mortality, with
particular burden at the extremes of age and in populations who are immunocompromised …
particular burden at the extremes of age and in populations who are immunocompromised …
Systemic prime mucosal boost significantly increases protective efficacy of bivalent RSV influenza viral vectored vaccine
C Bissett, S Belij-Rammerstorfer, M Ulaszewska… - npj Vaccines, 2024 - nature.com
Although licensed vaccines against influenza virus have been successful in reducing
pathogen-mediated disease, they have been less effective at preventing viral infection of the …
pathogen-mediated disease, they have been less effective at preventing viral infection of the …
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease
Alzheimer's disease (AD) is the sixth leading cause of death in the USA. It is established that
neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic …
neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic …
[HTML][HTML] Opposing effects of acellular and whole cell pertussis vaccines on Bordetella pertussis biofilm formation, Siglec-F+ neutrophil recruitment and bacterial …
JM Hall, JL Gutierrez-Ferman, MM Shamseldin, M Guo… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Despite global vaccination, pertussis caused by Bordetella pertussis (Bp) is resurging.
Pertussis resurgence is correlated with the switch from whole cell vaccines (wPV) that elicit …
Pertussis resurgence is correlated with the switch from whole cell vaccines (wPV) that elicit …
Use of Mucosally Administered Outer Membrane Vesicles Derived from Bordetella pertussis to Diminish Nasal Bacterial Colonization
Background: We previously identified Bordetella pertussis-derived outer membrane vesicles
(OMVs) as a promising immunogen for improving pertussis vaccines. In this study, we …
(OMVs) as a promising immunogen for improving pertussis vaccines. In this study, we …