Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …

Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Sodium/glucose cotransporter 2 (SGLT2) inhibitors exert important renoprotective effects in
the diabetic kidney, which cannot be readily explained by their actions to lower blood …

Various mechanisms in the mammalian body provide resilience against food deprivation
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from …

Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …

RY rheostat, whereas AMPK discerns the balance between ATP and AMP in the cytosol.
Importantly, SIRT1 and AMPK are activated not only by fasting but also by a broad range of …

Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier
of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also …

Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …