Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in
type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than …

Methods. Using keywords “mitochondria”,“kidney”,“proteomics”, scientific databases
(PubMed and Web of knowledge) were searched from 2000 to August 2015 for articles …

Mitochondrial hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme
in 21 ketogenesis. The liver expresses high levels of HMGCS2 constitutively as the main …

Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized
and critically ill patients, highlighted by a rapid decline of kidney function occurring a few …

Genetic disorders known as ciliopathies develop polycystic kidneys, including autosomal
dominant and autosomal recessive polycystic kidney diseases (ADPKD and ARPKD) …

Hemorrhagic Shock is the leading cause of preventable death after trauma. A combination of
4 M D-β-hydroxybutyrate and melatonin (BHB/M) improves survival in preclinical …

Insulin resistance, part of the metabolic syndrome, is associated with type 2 diabetes
mellitus (T2DM) and increased risk for Alzheimer's disease (AD). The ε4 allele of APOE is …

Dietary therapy has been used since ancient times to treat the symptoms of disease and
disorder. Dietary therapy has long captured the interest of the public in modern times, dating …

Metabolic acidosis is a physiological disturbance which results in a decrease in blood and
extracellular pH and HCO 3-. The renal response to this disturbance is initiated in the …