This review focuses on metabolomics from an NMR point of view. It attempts to cover the
broad scope of metabolomics and describes the NMR experiments that are most suitable for …

This review highlights recent advancements in using high resolution nuclear magnetic
resonance (NMR) spectroscopy as a characterization tool to expedite biologics formulation …

Two-dimensional (2D) 1H–13C methyl NMR provides a powerful tool to probe the higher
order structure (HOS) of monoclonal antibodies (mAbs), since spectra can readily be …

Monoclonal antibody (mAb) drugs constitute the largest class of protein therapeutics
currently on the market. Correctly folded protein higher order structure (HOS), including …

Methods for characterizing the higher-order structure of protein therapeutics are in great
demand for establishing consistency in drug manufacturing, for detecting drug product …

Assessing how excipients affect the self-association of monoclonal antibodies (mAbs)
requires informative and direct in situ measurements for highly concentrated solutions …

An important aspect in the analytical characterization of protein therapeutics is the
comprehensive characterization of higher order structure (HOS). Nuclear magnetic …

Peptide and protein drug molecules fold into higher order structures (HOS) in formulation
and these folded structures are often critical for drug efficacy and safety. Generic or …

Obtaining high ordered structure (HOS) information is of importance to guarantee the
efficacy and safety of monoclonal antibodies (mAbs) in clinical application. Assessment of …

The multiplicity-edited heteronuclear single quantum correlation (ME-HSQC) NMR method
is widely used for the structural characterization of marine dissolved organic matter (DOM) …