Folate may influence breast cancer development and progression through its role in one-
carbon metabolism. However, epidemiologic data on the relation between folate and breast …

Breast cancer (BC) represents a highly heterogeneous tumour at both the clinical and
molecular levels. Single-nucleotide polymorphisms (SNPs) of the folate-metabolising …

Advances in diagnostic screening and adjuvant therapy have dramatically increased the
number of breast cancer survivors in the USA, who may face changes in physical and …

Methylenetetrahydrofolate reductase (MTHFR) enzyme is essential for DNA synthesis and
DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth …

To better understand breast cancer etiology and progression, we explored the association
between promoter methylation status of three breast cancer-related genes (BRCA1, APC …

Panel-based next generation sequencing (NGS) is currently preferred over whole exome
sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges …

Alcohol continues to be a major contributor to morbidity and mortality globally. Despite the
scientific advances, alcohol use related problems continue to pose a major challenge to …

Background and aims The evidence regarding folate intake and mortality risk among
patients with type 2 diabetes (T2D) remains unclear. This study aimed to investigate the …

Folate is a water-soluble B-vitamin and is an important cofactor in one-carbon metabolism.
This vitamin plays an important role in the pathogenesis of several chronic diseases. In …

Polymorphisms in genes involved in folate metabolism have been shown to be implicated in
breast cancer risk but with contradictory results. In this case–control study, we investigated …