Cytotoxic T lymphocytes are effector CD8+ T cells that eradicate infected and malignant
cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse …

The opportunistic intracellular bacterial pathogen Listeria monocytogenes has in 30 years
emerged as an exceptional bacterial model system in infection biology. Research on this …

Listeria monocytogenes (Lm) infection induces robust CD8 T cell responses, which play a
critical role in resolving Lm during primary infection and provide protective immunity to re …

It could be argued that we understand the immune response to infection with Listeria
monocytogenes better than the immunity elicited by any other bacteria. L. monocytogenes …

CD8+ T cells are central mediators of immune responses against infections and cancer.
Here we identified Dapl1 as a crucial regulator of CD8+ T cell responses to cancer and …

Background Neuro-cognitive impairment is a deleterious complication of bacterial infections
that is difficult to treat or prevent. Listeria monocytogenes (Lm) is a neuroinvasive bacterial …

TLR2 signaling plays a critical protective role against acute Listeria monocytogenes (Lm)
infection by up-regulating inflammatory cytokines and promoting macrophage antimicrobial …

Background T-cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint
inhibitor that has therapeutic implications for many tumors and infectious diseases …

Generation and maintenance of antigen-specific effector and memory T cells are central
events in immune responses against infections. We show that TNF receptor-associated …

The facultative intracellular bacterium Listeria (L.) monocytogenes may cause severe
diseases in humans and animals. The control of listeriosis/L. monocytogenes requires the …