This study was designed to investigate the effects of Sparassis latifolia polysaccharides
(SLPs) on activation, proliferation and differentiation, and effect stage of CD8+ T cells in …

ThGM-CSF cells contribute to the protective immune response against Listeria monocytogenes
Page 1 Page 1/24 ThGM-CSF cells contribute to the protective immune response against …

More effective protection against tumors and intracellular pathogens requires a deeper
understanding of CD8 T-cell biology. We found that the progenitors of dysfunctional CD8 T …

Background Recent advances in the field of cancer immunotherapy have identified CD8+ T
cell responses against tumor-specific mutations as a key driver of tumor regression and …

Pathogens such as bacteria, viruses, fungi, or protozoa can cause acute and chronic
infections in their hosts. The intracellular bacterium Listeria monocytogenes serves as a …

We used a mouse model to study how Mycobacterium tuberculosis subverts host defenses
to persist in macrophages despite immune pressure. CD4 T cells can recognize …

In this thesis, the fate decisions of T cells leading to functional or exhausted subsets are
investigated at the single-cell level. Cell cycle speed measurements, single-cell fate …

The magnitude and effectiveness of CD8 response against intracellular pathogens is
directed by survival and apoptotic signals that govern the fate of T cells. XIAP is a bona fide …

Immune responses towards intracellular pathogens and tumours rely on CD8+ T
lymphocytes, whose function it is to kill infected or cancer cells, while sparing healthy tissue …

Background: Listeria monocytogenes is the causal agent of listeriosis, a foodborne infection.
Objectives: Osthole has antibacterial properties, but its mechanisms of action is still …