Durante las últimas décadas se han comenzado a desarrollar las denominadas “vacunas
de la nueva generación”. Su diseño difiere de las vacunas tradicionales y está basado en el …

South Africa recently experienced a Listeriosis outbreak, which was responsible for over 180
deaths, caused by an intracellular, rod-shaped bacilli called Listeria monocytogenes (LM) …

The impact of environmental pressures on the immune system is significant and complex.
External influences contribute to immune development, cause or impact diseases, and …

Abstract Activated PI3Kdelta Syndrome (APDS) is immunodeficiency caused by a
heterozygous gain-of-function mutation (E1021K) in the PIK3CD gene, encoding for the …

Listeria monocytogenes is an opportunistic foodborne pathogen responsible for listeriosis, a
potentially fatal foodborne disease. Many different Listeria strains and serotypes exist, but a …

Immunometabolism is fueling breakthroughs across oncology, infection control, and
inflammation research. It is appreciated that CD8 T cells are important players in all of the …

Phosphatidylinositide-3-Kinases (PI3Ks) are a family of lipid kinases that play important
intracellular signaling roles in cellular functions such as cell proliferation, motility, growth …

In this study we identified that restricting pyrimidine levels through pharmacological
treatment with leflunomide early during T cell activation blocks the differentiation of CD8+ …

Lors d'une infection, les lymphocytes T (LT) CD8 naïfs entre dans une phase de prolifération
rapide durant laquelle ils se différencient en LT effecteurs (LTe) capables d'éliminer l'agent …

Pathogenic microorganisms are already responsible for a significant burden of disease, and
this burden is predicted to grow as the prevalence of antimicrobial resistance rises. A …