[PDF][PDF] Analysis of T cell exhaustion observed in tumor suppressor Menin KO mice.

T Yamada - THE WAKSMAN FOUNDATION OF JAPAN INC. - waksman.or.jp
The main functions of antigen-experienced CD8+ T cells are to eliminate tumors and cells
infected with intracellular pathogens (1, 2). The goal of our vaccine and immunotherapeutic …

[图书][B] Examining the impact of methionine availability on T cell epigenetics

J Chen - 2017 - search.proquest.com
Epigenetic modifications on DNA and histones activate or repress gene transcription by
modulating chromatin accessibility to transcription machinery. This is linked to cellular …

[图书][B] Time-dependent alterations in memory CD8 T cell function after infection

MD Martin - 2016 - search.proquest.com
CD8 T cells play a critical role in the clearance of pathogenic bacteria, viruses, and
protozoan parasites. Upon encountering their cognate antigen through either infection or …

[图书][B] The generation and differentiation of memory CD8 T cell responses in health and disease

SH Khan - 2015 - search.proquest.com
Memory CD8 T cells offer increased protection to immune hosts by rapidly eliminating
pathogen-infected cells during re-infection. Generating and sustaining a protective memory …

The transcription factor NFATc1 mediates cytotoxic T cell function in vitro and in vivo

T Pusch - 2015 - opus.bibliothek.uni-wuerzburg.de
While numerous experiments on NFAT were already performed with CD4+ T cells showing
defective cytokine release and a reduced T helper cell development, no detailed studies …