The lung is the organ with the highest vascular density in the human body. It is therefore
perceivable that the endothelium of the lung contributes significantly to the circulation of …

The interest in extracellular vesicles (EVs) has grown exponentially over the last decade.
Evolving evidence is demonstrating that these EVs are playing an important role in health …

Microparticles are submicron vesicles shed from a variety of cells. Peter Wolf first identified
microparticles in the midst of ongoing blood coagulation research in 1967 as a product of …

Microparticles (MPs) are submicron vesicles released from cell membranes in response to
activation, cell injury, or apoptosis. The clinical importance of MPs has become increasingly …

Background Platelet activation and aggregation are critical in the pathogenesis of acute
ischemic stroke (AIS). Circulating platelet microparticles (PMPs) and platelet parameters are …

There is evidence that inflammatory bowel diseases (IBD) combine both inflammation and
coagulation in their pathogenesis and clinical manifestations. Although platelets (PLT) are …

Pulmonary arterial hypertension (PAH) is characterized by an important occlusive vascular
remodeling with the production of new endothelial cells, smooth muscle cells …

Objective: Extracellular vesicles (EVs) have the potential to act as intercellular
communicators. The aims were to characterize circulating EVs in patients with pulmonary …

(1) Background: Prostacyclin analogues (epoprostenol, treprostinil, and iloprost) induce
vasodilation in pulmonary arterial hypertension (PAH) but also inhibit platelet function.(2) …

Highlights•Thrombosis and excess platelet activation are key pathologic features of
pulmonary arterial hypertension (PAH).•Platelets are the main source of circulating …