Neoadjuvant immune checkpoint inhibitor therapy for localized deficient mismatch repair colorectal cancer: A review

OE Emiloju, FA Sinicrope - JAMA oncology, 2023 - jamanetwork.com
Importance Colorectal cancers (CRCs) with deficient DNA mismatch repair (dMMR) account
for 15% of all CRCs. Deficient MMR is a predictive biomarker associated with …

Anastomotic leak risk factors following colon cancer resection: a systematic review and meta-analysis

J He, M He, JH Tang, XH Wang - Langenbeck's Archives of Surgery, 2023 - Springer
Background Despite improved surgical techniques, anastomotic leakage is still a serious
complication that can occur after colon cancer resection, resulting in increased morbidity …

Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a …

L Xu, X Su, Z He, C Zhang, J Lu, G Zhang… - The Lancet …, 2021 - thelancet.com
Background Whether extended lymphadenectomy for right colon cancer leads to increased
perioperative complications or improves survival is still controversial. This trial aimed to …

Immune checkpoint blockade therapy in patients with colorectal cancer harboring microsatellite instability/mismatch repair deficiency in 2022

T André, R Cohen, ME Salem - American Society of Clinical Oncology …, 2022 - ascopubs.org
Immune checkpoint inhibitors (ICIs) are shown to be effective among patients with metastatic
colorectal cancer (mCRC) harboring high microsatellite instability (MSI-H) and/or mismatch …

Outcomes from elective colorectal cancer surgery during the SARS‐CoV‐2 pandemic

COVIDSurg Collaborative, JC Glasbey… - Colorectal …, 2021 - Wiley Online Library
Aim This study aimed to describe the change in surgical practice and the impact of SARS‐
CoV‐2 on mortality after surgical resection of colorectal cancer during the initial phases of …

Intracorporeal versus extracorporeal anastomosis in robotic right colectomy: a multicenter, triple-blind, randomized clinical trial

N Dohrn, H Yikilmaz, M Laursen, F Khesrawi… - 2022 - journals.lww.com
Objective: To determine if minimally invasive right colectomy with intra-corporeal
anastomosis improves postoperative recovery compared to extra-corporeal anastomosis …

An evaluation of the replicability of analyses using synthetic health data

K El Emam, L Mosquera, X Fang, A El-Hussuna - Scientific Reports, 2024 - nature.com
Synthetic data generation is being increasingly used as a privacy preserving approach for
sharing health data. In addition to protecting privacy, it is important to ensure that generated …

One-stage total laparoscopic treatment for colorectal cancer with synchronous metastasis. Is it safe and feasible?

G Sena, A Picciariello, F Marino, M Goglia… - Frontiers in …, 2021 - frontiersin.org
Liver is the main target organ for colorectal cancer (CRC) metastases. It is estimated that~
25% of CRC patients have synchronous metastases at diagnosis, and about 60% of CRC …

Aspects Towards the Anastomotic Healing in Crohn's Disease: Clinical Approach and Current Gaps in Research

FHM Chaim, LMV Negreiros, KM Steigleder… - Frontiers in …, 2022 - frontiersin.org
Anastomotic leakage is a major complication in gastrointestinal and colorectal surgery and
its occurrence increases morbidity and mortality. Its incidence is even higher in Crohn's …

Intracorporeal versus extracorporeal anastomosis for laparoscopic right hemicolectomy: short-term outcomes

A Biondi, G Di Mauro, R Morici, G Sangiorgio… - Journal of Clinical …, 2021 - mdpi.com
Laparoscopic right hemicolectomy represents an effective therapeutic approach for right
colon cancer (RCC). The primary aim of this study was to evaluate bowel function recovery …