Alzheimer's disease (AD) is the most common form of dementia in elder people,
characterised by a progressive decline in memory as a result of an impairment of cholinergic …

Abstract Development of Multi-Target Directed Ligands (MTDLs) has emerged as a
promising approach for targeting complex etiology of Alzheimer's disease (AD). Following …

Aiming at modulating two key enzymatic targets for Alzheimer's disease (AD), ie,
acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), a series of multitarget …

Alzheimer's disease (AD) is a severe age-dependent neurodegenerative disorder affecting
millions of people, with no cure so far. The current treatments only achieve some temporary …

Alzheimer's disease is a progressive and irreversible neurodegenerative disease,
associated with a decreased cognitive function and severe behavioral abnormalities. Due to …

A series of novel chalcone-O-alkylamine derivatives were designed, synthesized and
evaluated as multifunctional anti-Alzheimer's disease agents. Based on the experimental …

Photochromic cholinesterase inhibitors were obtained from cis-1, 2-α-dithienylethene-based
compounds by incorporating one or two aminopolymethylene tacrine groups. All target …

A series of sulfone analogs of donepezil were designed and synthesized as novel
acetylcholinesterase (AChE) inhibitors with the potent inhibiting Aβ aggregation and …

Combining N-benzylpiperidine moiety of donepezil and coumarin into in a single molecule,
novel hybrids with ChE and MAO-B inhibitory activity were designed and synthesized. The …

Combining N-benzyl pyridinium moiety and coumarin into in a single molecule, novel
hybrids with ChE and MAO-B inhibitory activities were designed and synthesized. The …