ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker
Z Liu, B Zhang, S Xia, L Fang, S Gou - European journal of medicinal …, 2021 - Elsevier
Current drugs available in clinic for Alzheimer's disease (AD) treatment can only alleviate
disease symptoms without clearly curing or delaying the process of AD. And some AD drugs …
disease symptoms without clearly curing or delaying the process of AD. And some AD drugs …
New Melatonin–N,N-Dibenzyl(N-methyl)amine Hybrids: Potent Neurogenic Agents with Antioxidant, Cholinergic, and Neuroprotective Properties as Innovative …
B Lopez-Iglesias, C Perez… - Journal of medicinal …, 2014 - ACS Publications
Here, we describe a new family of melatonin–N, N-dibenzyl (N-methyl) amine hybrids that
show a balanced multifunctional profile covering neurogenic, antioxidant, cholinergic, and …
show a balanced multifunctional profile covering neurogenic, antioxidant, cholinergic, and …
Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer's …
JS Lan, JW Hou, Y Liu, Y Ding, Y Zhang… - Journal of enzyme …, 2017 - Taylor & Francis
A novel family of cinnamic acid derivatives has been developed to be multifunctional
cholinesterase inhibitors against AD by fusing N-benzyl pyridinium moiety and different …
cholinesterase inhibitors against AD by fusing N-benzyl pyridinium moiety and different …
Polypharmacology of dopamine receptor ligands
S Butini, K Nikolic, S Kassel, H Brückmann… - Progress in …, 2016 - Elsevier
Most neurological diseases have a multifactorial nature and the number of molecular
mechanisms discovered as underpinning these diseases is continuously evolving. The old …
mechanisms discovered as underpinning these diseases is continuously evolving. The old …
Recent developments on synthesis strategies, SAR studies and biological activities of β-Carboline derivatives–an update
The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …
of these alkaloids and their derivatives have been found to show significant biological …
[HTML][HTML] Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice
Y Zhou, Y Duan, S Huang, X Zhou, L Zhou, T Hu… - International journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common degenerative disease of the central nervous
system. It is associated with abnormal accumulation of amyloid-β (Aβ) plaques, impaired …
system. It is associated with abnormal accumulation of amyloid-β (Aβ) plaques, impaired …
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease
A series of genistein derivatives with carbon spacer-linked alkylbenzylamines were
designed, synthesized and tested as multifunctional agents for the treatment of Alzheimer's …
designed, synthesized and tested as multifunctional agents for the treatment of Alzheimer's …
Dual inhibitors of AChE and BACE-1 for reducing Aβ in Alzheimer's disease: from in silico to in vivo
N Stern, A Gacs, E Tátrai, B Flachner, I Hajdú… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a complex and widespread condition, still not fully understood
and with no cure yet. Amyloid beta (Aβ) peptide is suspected to be a major cause of AD, and …
and with no cure yet. Amyloid beta (Aβ) peptide is suspected to be a major cause of AD, and …
7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
J Korabecny, R Dolezal, P Cabelova, A Horova… - European journal of …, 2014 - Elsevier
A novel series of 7-methoxytacrine (7-MEOTA)–donepezil like compounds was synthesized
and tested for their ability to inhibit electric eel acetylcholinesterase (EeAChE), human …
and tested for their ability to inhibit electric eel acetylcholinesterase (EeAChE), human …
ASS234, as a new multi-target directed propargylamine for Alzheimer's disease therapy
J Marco-Contelles, M Unzeta, I Bolea… - Frontiers in …, 2016 - frontiersin.org
Highlights: ASS2324 is a hybrid compound resulting from the juxtaposition of donepezil and
the propargylamine PF9601N ASS2324 is a multi-target directed propargylamine able to …
the propargylamine PF9601N ASS2324 is a multi-target directed propargylamine able to …