As the central figure of the cellular protein degradation machinery, the proteasome is critical
for cell survival. Having been extensively targeted for inhibition, the constitutive proteasome …

Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

The ubiquitin-proteasome system (UPS) is the major non-lysosomal proteolytic system for
the degradation of abnormal or damaged proteins no longer required. The proteasome is …

We describe noncovalent, reversible asparagine ethylenediamine (AsnEDA) inhibitors of the
Plasmodium falciparum proteasome (Pf20S) β5 subunit that spare all active subunits of …

Proteasomes are compartmentalized, ATP-dependent, N-terminal nucleophile hydrolases
that play essentials roles in intracellular protein turnover. They are present in all 3 kingdoms …

Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of
multiple B-cell malignancies. These agents have also been employed with success in the …

The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading
not only misfolded or oxidized proteins but also proteins with essential functions. The fact …

The immunoproteasome, a specialized form of proteasome, is mainly expressed in
lymphocytes and monocytes of jawed vertebrates and responsible for the generation of …

Highlights•Structure–function relationship of subunit selective proteasome inhibitors.•
Development and characterization of new inhibitors of the immunoproteasome.•Modulation …

Proteasomes are multisubunit, energy‐dependent, proteolytic complexes that play an
essential role in intracellular protein turnover. They are present in eukaryotes, archaea, and …