Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning

P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

[HTML][HTML] Corneal neovascularization: updates on pathophysiology, investigations & management

Z Sharif, W Sharif - Romanian journal of ophthalmology, 2019 - ncbi.nlm.nih.gov
Objective. Corneal neovascularization is a sight-threatening condition affecting more than
1.4 million people per year. Left untreated, it can lead to tissue scarring, oedema, lipid …

[HTML][HTML] Pathogenesis of herpes stromal keratitis: immune inflammatory response mediated by inflammatory regulators

L Wang, R Wang, C Xu, H Zhou - Frontiers in Immunology, 2020 - frontiersin.org
Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even
blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is …

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea

L Koujah, RK Suryawanshi, D Shukla - Cellular and molecular life …, 2019 - Springer
Herpes simplex virus type-1 (HSV-1) is a ubiquitous pathogen that infects a large majority of
the human population worldwide. It is also a leading cause of infection-related blindness in …

Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology

A Suryawanshi, T Veiga-Parga… - The Journal of …, 2011 - journals.aai.org
HSV-1 infection of the cornea leads to a blinding immunoinflammatory lesion of the eye
termed stromal keratitis (SK). Recently, IL-17–producing CD4+ T cells (Th17 cells) were …

[HTML][HTML] Tear film micrornas as potential biomarkers: a review

J Altman, G Jones, S Ahmed, S Sharma… - International journal of …, 2023 - mdpi.com
MicroRNAs are non-coding RNAs that serve as regulatory molecules in a variety of
pathways such as inflammation, metabolism, homeostasis, cell machinery, and …

[HTML][HTML] VEGF upregulation in viral infections and its possible therapeutic implications

KR Alkharsah - International journal of molecular sciences, 2018 - mdpi.com
Several viruses are recognized as the direct or indirect causative agents of human tumors
and other severe human diseases. Vascular endothelial growth factor (VEGF) is identified as …

[PDF][PDF] Production of the cytokine VEGF-A by CD4+ T and myeloid cells disrupts the corneal nerve landscape and promotes herpes stromal keratitis

H Yun, MB Yee, KL Lathrop, PR Kinchington… - Immunity, 2020 - cell.com
Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding
immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss …

[HTML][HTML] Role of miR-132 in angiogenesis after ocular infection with herpes simplex virus

S Mulik, J Xu, PBJ Reddy, NK Rajasagi… - The American journal of …, 2012 - Elsevier
MicroRNAs (miRNAs) are small regulatory molecules that control diverse biological
processes that include angiogenesis. Herpes simplex virus (HSV) causes a chronic immuno …

Pathogenesis of herpes stromal keratitis–a focus on corneal neovascularization

F Giménez, A Suryawanshi, BT Rouse - Progress in retinal and eye …, 2013 - Elsevier
The cornea is a complex sensory organ that must maintain its transparency for optimal
vision. Infections such as with herpes simplex virus can result in blinding …