Human T-cell lymphotropic virus type-1: a lifelong persistent infection, yet never truly silent

A Hirons, G Khoury, DFJ Purcell - The Lancet Infectious Diseases, 2021 - thelancet.com
Human T-cell lymphotropic virus type-1 (HTLV-1) has a large global burden and in some key
communities, such as Indigenous Australians living in remote areas, greater than 45% of …

[HTML][HTML] Novel treatments of adult T cell leukemia lymphoma

H El Hajj, K Tsukasaki, M Cheminant… - Frontiers in …, 2020 - frontiersin.org
Adult T cell leukemia-lymphoma (ATL) is an aggressive malignancy secondary to chronic
infection with the human T cell leukemia virus type I (HTLV-I) retrovirus. ATL carries a dismal …

[HTML][HTML] NK cells and monocytes modulate primary HTLV-1 infection

R Moles, S Sarkis, V Galli, M Omsland, M Artesi… - PLoS …, 2022 - journals.plos.org
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1
infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type …

Therapeutic approaches for HTLV-1-associated adult T-cell leukemia/lymphoma: a comprehensive review

A Letafati, R Soheili, M Norouzi, P Soleimani… - Medical Oncology, 2023 - Springer
Adult T-cell leukemia/lymphoma (ATLL), an infrequent malignancy resultant from human T-
cell lymphotropic virus type I (HTLV-1), exhibits a spectrum of phenotypes, encompassing …

[HTML][HTML] Epitope-based universal vaccine for Human T-lymphotropic virus-1 (HTLV-1)

MT Raza, S Mizan, F Yasmin, AS Akash, SM Shahik - PloS one, 2021 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) was the first oncogenic human retrovirus
identified in humans which infects at least 10–15 million people worldwide. Large HTLV-1 …

HTLV‐1 persistent infection and ATLL oncogenesis

X Zuo, R Zhou, S Yang, G Ma - Journal of Medical Virology, 2023 - Wiley Online Library
Human T‐cell leukemia virus type 1 (HTLV‐1) was discovered in the 1980s, but it is
estimated to have been infecting humans for more than ten thousand years. 1 With over 90 …

[HTML][HTML] Transcriptome-based analysis of human peripheral blood reveals regulators of immune response in different viral infections

SM Ivanov, OA Tarasova, VV Poroikov - Frontiers in Immunology, 2023 - frontiersin.org
Introduction There are difficulties in creating direct antiviral drugs for all viruses, including
new, suddenly arising infections, such as COVID-19. Therefore, pathogenesis-directed …

[HTML][HTML] Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell …

H El Hajj, A Bazarbachi - Frontiers in Immunology, 2022 - frontiersin.org
The Human T-cell Leukemia virus type 1 (HTLV-1) causes an array of pathologies, the most
aggressive of which is adult T-cell leukemia (ATL), a fatal blood malignancy with dismal …

Epidemiology of adult T‐cell leukemia‐lymphoma in Japan: An updated analysis, 2012‐2013

S Ito, M Iwanaga, K Nosaka, Y Imaizumi… - Cancer …, 2021 - Wiley Online Library
Adult T‐cell leukemia‐lymphoma (ATL) is a T‐cell malignancy that is endemic to Japan. In
this latest nationwide study of ATL, we collected the data from 4 nationwide registries of …

Selective APC-targeting of a novel Fc-fusion multi-immunodominant recombinant protein (tTax-tEnv: mFcγ2a) for HTLV-1 vaccine development

M Shafifar, SH Mozhgani, KR Pashabayg, A Mosavat… - Life Sciences, 2022 - Elsevier
Aims HTLV-1 causes two life-threatening diseases: adult T-cell leukaemia/lymphoma and
HTLV-1-associated myelopathy/tropical spastic paraparesis. Due to the lack of proper …