Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges
J Ritterhoff, R Tian - Nature Reviews Cardiology, 2023 - nature.com
Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …
[HTML][HTML] The Mitochondrial ATP Synthase/IF1 Axis in Cancer Progression: Targets for Therapeutic Intervention
S Domínguez-Zorita, JM Cuezva - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a global health problem with high personal and economic
burden worldwide. The reprogramming of metabolism experienced by carcinomas offers a …
burden worldwide. The reprogramming of metabolism experienced by carcinomas offers a …
[HTML][HTML] IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory …
S Domínguez-Zorita, I Romero-Carramiñana… - Cell Death & …, 2023 - nature.com
Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
[HTML][HTML] The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis
C Galber, S Fabbian, C Gatto, M Grandi… - Cell death & …, 2023 - nature.com
The mitochondrial protein IF1 binds to the catalytic domain of the ATP synthase and inhibits
ATP hydrolysis in ischemic tissues. Moreover, IF1 is overexpressed in many tumors and has …
ATP hydrolysis in ischemic tissues. Moreover, IF1 is overexpressed in many tumors and has …
[HTML][HTML] IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential
I Romero-Carramiñana, PB Esparza-Moltó… - Communications …, 2023 - nature.com
The coexistence of two pools of ATP synthase in mitochondria has been largely neglected
despite in vitro indications for the existence of reversible active/inactive state transitions in …
despite in vitro indications for the existence of reversible active/inactive state transitions in …
[HTML][HTML] Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies
S Daneshmandi, JE Choi, Q Yan… - Nature …, 2024 - nature.com
Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and
correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC …
correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC …
Differential expression of nuclear-encoded mitochondrial protein genes of ATP synthase across different tissues of female buffalo
EM Sadeesh, MS Lahamge, A Malik… - Molecular Biotechnology, 2024 - Springer
The physiological well-being of buffaloes, encompassing phenotypic traits, reproductive
health, and productivity, depends on their energy status. Mitochondria, the architects of …
health, and productivity, depends on their energy status. Mitochondria, the architects of …
[HTML][HTML] The ATPase Inhibitory Factor 1 (IF1) Contributes to the Warburg Effect and Is Regulated by Its Phosphorylation in S39 by a Protein Kinase A-like Activity
JM Cuezva, S Domínguez-Zorita - Cancers, 2024 - mdpi.com
Simple Summary The ATPase Inhibitory Factor 1 (IF1) plays a prominent role as an inhibitor
of mitochondrial ATP synthase. Herein we review the role of IF1 in promoting the Warburg …
of mitochondrial ATP synthase. Herein we review the role of IF1 in promoting the Warburg …
An updated review of YAP: A promising therapeutic target against cardiac aging?
J Leng, C Wang, Z Liang, F Qiu, S Zhang… - International Journal of …, 2024 - Elsevier
The transcriptional co-activator Yes-associated protein (YAP) functions as a downstream
effector of the Hippo signaling pathway and plays a crucial role in cardiomyocyte survival. In …
effector of the Hippo signaling pathway and plays a crucial role in cardiomyocyte survival. In …
[HTML][HTML] IF1 Promotes Cellular Proliferation and Inhibits Oxidative Phosphorylation in Mouse Embryonic Fibroblasts under Normoxia and Hypoxia
L Lauterboeck, SW Kang, D White III, R Bao… - Cells, 2024 - mdpi.com
ATP synthase inhibitory factor subunit 1 (IF1) is an inhibitory subunit of mitochondrial ATP
synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is …
synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is …