At the turn of the century, Ehrlich (1957) proposed that the immunity to autologous antigen is
highly abnormal and would result in a disease process. At midcentury, Burnet (1959) …

Publisher Summary The chapter emphasizes the allogeneic as well as syngeneic and
autologous mixed lymphocyte reactions (MLR) are in vitro manifestations of cellular …

The clonal selection approach is simple and direct:“(1) It is necessary for survival that neither
immunocytes nor antibodies should exist in the body which are reactive to more than a …

To investigate the specific nature of the autologous mixed lymphocyte reaction (AMLR), we
applied a method in which mixtures of NY-nonadherent responder cells and NY-adherent …

The AMLR is decreased in chronic lymphocytic leukaemia (CLL), which is characterized by
a monoclonal expansion of CD5+ B lymphocytes. Since B cells are used to stimulate the …

Numerous studies have been published on the cellular immune reactivity of patients with
rheumatoid arthritis (RA) clearly indicating the involvement of cellular immune mechanisms …

Publisher Summary Subpopulations of natural killer (NK) cells, distinguishable by their
selectivity in cytotoxic interactions with given targets, seem to function preferentially in …

In patients with Hodgkin's disease, the impaired immune reactivity, especially of the thymus
dependent system, is well established. This decreased immune response of the …

Two major issues remain unresolved for both B cells and T cells:(i) How and when is the
specificity repertoire generated? and (ii) How is tolerance to self established and …

MATERIALS AND METHODS.. 22 Animals 22 Tissue Culture Cells. 22 Preparation of
Lymphoid Cells'. 22 Induction of Immunity 23 Cytotoxicity Assay....... 2k L Cells as Targets 2k …