Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …

Chemokines are involved in cellular interactions and tropism in situations frequently
associated with inflammation. Recently, the importance of chemokines and chemokine …

Millions of people worldwide suffer from neuropathic pain as a result of damage to or
dysfunction of the nervous system under various disease conditions. Development of …

Chemokines are a class of small chemotactic molecules with cytokine-like functions, which
are well known to orchestrate inflammatory responses within different organs. Overall, more …

The years 2000 and 2007 witnessed milestones in current understanding of G protein-
coupled receptor (GPCR) structural biology. In 2000 the first GPCR, bovine rhodopsin, was …

Co‐ordinated movement and controlled positioning of leucocytes is key to the development,
maintenance and proper functioning of the immune system. Chemokines and their receptors …

This review presents evidence that dual targeting of CCR2 and CCR5 has greater
therapeutic potential than targeting either receptor alone. A cardinal feature of inflammation …

Chemokines are a class of small cytokine-like molecules that orchestrate immune cell
infiltration into the liver in response to acute and chronic injuries. Apart from their …

Background The aim of this study was to provide more insight into the question as to why
blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis …

Major indications for use of peptide-based therapeutics include endocrine functions
(especially diabetes mellitus and obesity), infectious diseases, and cancer. Whereas some …