Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

Infections are important factors contributing to the morbidity and mortality among elderly
patients. High rates of consumption of antimicrobial agents by the elderly may result in …

Background Standard antibiotic dosing is not suitable for critically ill patients, due to altered
pharmacokinetics (PK) in these patients. Knowledge of protein binding is important for …

In the present study, population pharmacokinetic (PK) analysis was performed based on
meropenem data from a prospective study conducted in 114 critically ill patients with a wide …

Purpose This study aimed to investigate the pharmacokinetics and target attainment of
meropenem and compare the effect of meropenem dosing regimens in critically ill patients …

In the intensive care unit (ICU), infection-related mortality is high. Although adequate
antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up …

Introduction Population pharmacokinetic studies of β-lactam antimicrobials in critically ill
patients derive models that inform their dosing. In non-linear mixed-effects modelling …

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …

Objectives Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD)
attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired …

Background Several studies report lack of meropenem pharmacokinetic/pharmacodynamic
(PK/PD) target attainment (TA) and risk of therapeutic failure with intermittent bolus infusions …