Background Dietary fat is one of the most important energy sources of all the nutrients. Fatty
acids, stored as triacylglycerols (also called triglycerides) in the body, are an important …

OBJECTIVE: Patients with dyslipoproteinemia constitute the largest risk group for
development of atherosclerosis and cardiovascular disease (CVD). Despite extensive statin …

The identification of defective structures in the ATP-binding cassette (ABC) transporters
ABCG5 and ABCG8 in patients with sitosterolemia suggests that these two proteins are an …

The first four reviews in this series (Steinberg, D. 2004. J. Lipid Res. 45: 1583–1593;
Steinberg, D. 2005. J. Lipid Res. 46: 179–190; Steinberg, D. 2005. J. Lipid Res. 46: 2037 …

Purpose The objective was to systematically review clinical trial data on the effects of statins
on high-density lipoproteins (HDL) and to examine the possibility that this provides …

Dyslipidemia is a fundamental risk factor for cardiovascular diseases (CVDs) and can
worsen the prognosis, if unaddressed. Lipid guidelines are still evolving as dyslipidemia is …

OBJECTIVE:: The purpose of this study was to evaluate the efficacy and safety profile of
ezetimibe/simvastatin (EZE/SIMVA) combination tablet, relative to ezetimibe (EZE) and …

Ezetimibe is a cholesterol absorption inhibitor that blocks the intestinal absorption of both
biliary and dietary cholesterol. It appears to exert its effect by blocking intestinal sterol …

Background Cholesterol cholelithiasis is a multifactorial disease influenced by a complex
interaction of genetic and environmental factors and represents a failure of biliary …

The small intestine is a unique organ providing dietary and reabsorbed biliary cholesterol to
the body. However, the molecular mechanisms whereby cholesterol is absorbed have not …