The contributions of cooperative groups to performing large-cohort clinical trials and long-
term survivorship studies have facilitated advances in treatment, supportive care and …

Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

Importance Whole-exome sequencing (WES) has the potential to reveal tumor and germline
mutations of clinical relevance, but the diagnostic yield for pediatric patients with solid …

The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse
intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to …

Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year
survivors of childhood cancer. Patients and Methods Participants in the Childhood Cancer …

Abstract Purpose of Review Pediatric low-grade gliomas and glioneuronal tumors (pLGG)
account for approximately 30% of pediatric CNS neoplasms, encompassing a …

Critical discoveries over the past two decades have transformed our understanding of
medulloblastoma from a single entity into a clinically and biologically heterogeneous …

BACKGROUND AND PURPOSE: While there have been recent reports of brain retention of
gadolinium following gadolinium-based contrast agent administration in adults, a …

Cancer is a leading cause of death in children with tumors of the central nervous system, the
most commonly encountered solid malignancies in this population. Radiotherapy (RT) is an …

Background: Approximately 30% of children with medulloblastoma (MB) experience
recurrence, which is usually incurable. This study compared the overall survival (OS) of …