The late onset of necrosis and fibrosis in normal tissues can be a serious consequence of
radiotherapy in cancer patients. Because radiation‐induced vascular injury precedes the …

There is a rapid onset of organizing alveolitis/fibrosis at 120–140 d after whole lung
irradiation of C57BL/6J mice. To test the hypothesis that circulating cells of bone marrow …

Increased expression of intercellular adhesion molecule 1 (ICAM-1; CD54) is induced by
exposure to ionizing radiation. The lung was used as a model to study the role of ICAM-1 in …

Organ and tissue damage caused by ionizing irradiation is directly related to volume
irradiated, total dose and dose rate. The acute effects are in part mediated by cellular …

Introduction: In experimental animal models, biological sex-differences in the manifestation
and severity of normal tissue radiation injury have been well-documented. Previously we …

Inflammatory cell infiltration of the lung is a predominant histopathological change that
occurs during radiation pneumonitis. Emigration of inflammatory cells from the circulation …

Background Pulmonary arterial hypertension (PAH) is a commonly fatal pulmonary vascular
disease that is often diagnosed late and is characterised by a progressive rise in pulmonary …

Intraesophageal administration of manganese superoxide dismutase‐plasmid/liposome
(MnSOD‐PL) prior to single fraction radiation has been shown to protect mice from lethal …

Purpose: Radiation-induced pneumonitis and subsequent pulmonary fibrosis are important
dose-limiting complications of radiotherapy. Their pathogenesis is known onlyin part. T …

Background: Therapy-induced inflammation and progressive fibrosis limit the efficacy of
thoracic radiotherapy for lung neoplasms. However, mice bearing a null mutation of …