Invasive ductal carcinoma (IDC) is the most common histological subtype of malignant
breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great …

Breast cancer is the most common malignant cancer in women worldwide. Cancer
metastasis is the major cause of cancer-related deaths. BCKDK is associated with various …

Androgen has been shown to regulate male physiological activities and cancer proliferation.
It is used to antagonize estrogen-induced proliferative effects in breast cancer cells …

Targeted therapies have increased the treatment options for triple-negative breast cancer
patients. However, the paucity of targetable biomarkers and tumor heterogeneity have …

Abstract Background The R-RAS2 is a small GTPase highly similar to classical RAS proteins
at the regulatory and signaling levels. The high evolutionary conservation of R-RAS2, its …

Insufficient pancreatic β-cell mass and reduced insulin expression are key events in the
pathogenesis of diabetes mellitus (DM). Here we demonstrate the high expression of Talin-1 …

Background Psoralea corylifolia is a medicinal leguminous plant that has long been used to
treat various diseases. Psoralidin (PSO) is the main extract compound of P. corylifolia and …

Trigonelline (TRIG) is a natural compound in an alkaloid family found in diverse plants. This
compound exerts anti-inflammatory, anti-allergic, anti-oxidative and anti-fibrotic activities in …

Protein synthesis in response to neuronal activity, known as activity-dependent translation,
is critical for synaptic plasticity and memory formation. However, the signaling cascades that …

Abstract Talin protein (Talin 1/2) is a mechanosensitive cytoskeleton protein. The unique
structure of the Talin plays a vital role in transmitting mechanical forces. Talin proteins …