The lymphatic system has important roles in body fluid regulation, macromolecular
homeostasis, lipid absorption, and immune function. To accomplish these roles, lymphatics …

The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well
as in immunosurveillance and removal of interstitial fluid. Historically, despite its crucial …

Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease
status provides great prognostic power, but how lymph node metastases should be treated …

T cell migration within and between peripheral tissues and secondary lymphoid organs is
essential for proper functioning of adaptive immunity. While active T cell migration within a …

The tumor microenvironment (TME) is a key factor regulating tumor cell invasion and
metastasis. The effects of biochemical factors such as stromal cells, immune cells, and …

Fluid shear forces have established roles in blood vascular development and function, but
whether such forces similarly influence the low-flow lymphatic system is unknown. It has …

The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as
key players that maintain human health through their functional roles in tissue fluid …

Dendritic cell (DC) migration to draining lymph nodes (dLNs) is a slow process that is
believed to begin with DCs approaching and entering into afferent lymphatic capillaries …

During metastasis, cancer cells are exposed to potentially destructive hemodynamic forces
including fluid shear stress (FSS) while en route to distant sites. However, prior work …

Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that
line the blood and lymphatic vessels. The magnitude, pulsatility, and directional …