Pathological angiogenesis: mechanisms and therapeutic strategies
AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …
existing ones, is an essential process for growth and development. Different mechanisms …
[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)
RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
The endothelium–bone axis in development, homeostasis and bone and joint disease
J Tuckermann, RH Adams - Nature Reviews Rheumatology, 2021 - nature.com
Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …
processes such as tissue oxygenation, metabolism and immune surveillance. The …
Angiocrine functions of organ-specific endothelial cells
Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …
[HTML][HTML] Generation of functional human pancreatic β cells in vitro
FW Pagliuca, JR Millman, M Gürtler, M Segel… - Cell, 2014 - cell.com
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in …
an unprecedented cell source for drug discovery and cell transplantation therapy in …
Insulin: the friend and the foe in the development of type 2 diabetes mellitus
N Rachdaoui - International journal of molecular sciences, 2020 - mdpi.com
Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …
Modeling mouse and human development using organoid cultures
In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …
The perivascular niche regulates breast tumour dormancy
In a significant fraction of breast cancer patients, distant metastases emerge after years or
even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and …
even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and …
[HTML][HTML] Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
A Armulik, G Genové, C Betsholtz - Developmental cell, 2011 - cell.com
Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators
of vascular morphogenesis and function during development, cardiovascular homeostasis …
of vascular morphogenesis and function during development, cardiovascular homeostasis …
Vascularized and complex organ buds from diverse tissues via mesenchymal cell-driven condensation
Transplantation of in-vitro-generated organ buds is a promising approach toward
regenerating functional and vascularized organs. Though it has been recently shown in the …
regenerating functional and vascularized organs. Though it has been recently shown in the …