X-linked hypophosphataemia (XLH) is the most common cause of inherited phosphate
wasting and is associated with severe complications such as rickets, lower limb deformities …

Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and
osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such …

Background X-linked hypophosphatemia is characterized by increased secretion of
fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently …

Background X-linked hypophosphataemia in children is characterised by elevated serum
concentrations of fibroblast growth factor 23 (FGF23), hypophosphataemia, rickets, lower …

Dietary calcium deficiency is considered to be widespread globally, with published
estimates suggesting that approximately half of the world's population has inadequate …

Vitamin D testing and treatment is a subject of controversial scientific discussions, and it is
challenging to navigate through the expanding vitamin D literature with heterogeneous and …

Context X-linked hypophosphatemia (XLH) is characterized by excess fibroblast growth
factor 23 (FGF23), hypophosphatemia, skeletal abnormalities, and growth impairment. We …

Context Younger age at treatment onset with conventional therapy (phosphate salts and
active vitamin D; Pi/D) is associated with improved growth and skeletal outcomes in children …

Severe vitamin D deficiency can be defined as the dose of vitamin D or serum 25OHD
concentrations needed to prevent nutritional rickets or osteomalacia. There is large …

Background Children with X-linked hypophosphataemia have high concentrations of
circulating phosphatonin fibroblast growth factor 23 (FGF23), which causes renal phosphate …