Aortic valve stenosis: from basic mechanisms to novel therapeutic targets

PR Goody, MR Hosen, D Christmann… - … , and vascular biology, 2020 - Am Heart Assoc
Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …

Impact of cholesterol metabolism in immune cell function and atherosclerosis

M Aguilar-Ballester, A Herrero-Cervera, Á Vinué… - Nutrients, 2020 - mdpi.com
Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

Lipoprotein (a)—the crossroads of atherosclerosis, atherothrombosis and inflammation

S Ugovšek, M Šebeštjen - Biomolecules, 2021 - mdpi.com
Increased lipoprotein (a)(Lp (a)) levels are an independent predictor of coronary artery
disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD …

The molecular basis of predicting atherosclerotic cardiovascular disease risk

M Nayor, KJ Brown, RS Vasan - Circulation research, 2021 - Am Heart Assoc
Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages:
initiation, progression (or regression), and complications. By integrating known biology …

Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report

M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …

Lipoprotein (a): a genetic marker for cardiovascular disease and target for emerging therapies

A Cesaro, A Schiavo, E Moscarella… - Journal of …, 2021 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is an established cardiovascular risk factor, and growing
evidence indicates its causal association with atherosclerotic disease because of the …

Lipoprotein (a) the insurgent: a new insight into the structure, function, metabolism, pathogenicity, and medications affecting lipoprotein (a) molecule

MM Jawi, J Frohlich, SY Chan - Journal of lipids, 2020 - Wiley Online Library
Lipoprotein (a)[Lp (a)], aka “Lp little a”, was discovered in the 1960s in the lab of the
Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of …

Cardiovascular disease risk in rheumatoid arthritis anno 2022

B Dijkshoorn, R Raadsen, MT Nurmohamed - Journal of clinical medicine, 2022 - mdpi.com
The risk for developing cardiovascular diseases (CVD) in rheumatoid arthritis (RA) patients
is 1.5 times higher compared to the general population. This risk is partly due to the …

Novel biomarkers of atherosclerotic vascular disease—Latest insights in the research field

CA Adam, DL Șalaru, C Prisacariu, DTM Marcu… - International journal of …, 2022 - mdpi.com
The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is
attributed to atherosclerosis, from its appearance to its associated complications. The …

Dietary antioxidants remodel DNA methylation patterns in chronic disease

M Beetch, S Harandi‐Zadeh, K Shen… - British journal of …, 2020 - Wiley Online Library
Chronic diseases account for over 60% of all deaths worldwide according to the World
Health Organization reports. Majority of cases are triggered by environmental exposures that …