High levels of aneuploidy and chromosomal instability (CIN) are correlated with poor patient
outcomes, though the mechanism (s) underlying this relationship have not been established …

Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a
driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately …

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …

Background High-grade serous ovarian cancer (HGSOC) is the most common and lethal
ovarian cancer histotype. Chromosome instability (CIN, an increased rate of chromosome …

Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its
immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that …

Objective High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological
malignancy in women with a high level of mortality, metastatic disease, disease recurrence …

Despite high-grade serous ovarian cancer (HGSOC) being the most common and lethal
gynecological cancer in women, the early etiological events driving disease development …

Proteolysis targeting chimeras (PROTAC) are an emerging precision medicine strategy,
which targets key proteins for proteolytic degradation to ultimately induce cancer cell killing …

This review investigates the role of aneuploidy and chromosome instability (CIN) in the
aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the …

Chromosome instability (CIN), or progressive changes in chromosome numbers, is an
enabling feature of many cancers; however, the mechanisms giving rise to CIN remain …