Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …

The application of metabolomics in translational research suffers from several technological
bottlenecks, such as data reproducibility issues and the lack of standardization of sample …

Elimination or mitigation of the toxic effects of chemical waste released to the environment
by industrial and urban activities relies largely on the catalytic activities of microorganisms …

The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here
we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO) …

Metabolomics is the systematic study of all the metabolites present within a biological
system, which consists of a mass of molecules, having a variety of physical and chemical …

In metabolism, available free energy is limited and must be divided across pathway steps to
maintain a negative Δ G throughout. For each reaction, Δ G is log proportional both to a …

Metabolites, the chemical entities that are transformed during metabolism, provide a
functional readout of cellular biochemistry. With emerging technologies in mass …

Continuing improvements in analytical technology along with an increased interest in
performing comprehensive, quantitative metabolic profiling, is leading to increased interest …

Metabolomics aims at detection and quantitation of all metabolites in biological samples.
The presence of metabolites with a wide variety of physicochemical properties and different …