Spermatogenesis is completely dependent on the pituitary hormone follicle-stimulating
hormone (FSH) and androgens locally produced in response to luteinising hormone (LH) …

Mammalian spermatogenesis is a classic adult stem cell–dependent process, supported by
self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Spo11, a protein first identified in yeast, is thought to generate the chromosome breaks that
initiate meiotic recombination. We now report that disruption of mouse Spo11 leads to …

Stem cells support tissue maintenance by balancing self-renewal and differentiation. In
mice, it is believed that a homogeneous stem cell population of single spermatogonia …

The switch from mitosis to meiosis is a unique feature of germ cell development. In
mammals, meiotic initiation requires retinoic acid (RA), which activates meiotic inducers …

Spermatogenesis, a study of germ cell development, is a long, orderly, and well‐defined
process occurring in seminiferous tubules of the testis. It is a temporal event whereby …

Sperm and egg production requires a robust stem cell system that balances self-renewal
with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis …

The maintenance of cycling cell lineages relies on undifferentiated subpopulations
consisting of stem and progenitor pools. Features that delineate these cell types are …

The recently developed testis cell transplantation method provides a powerful approach to
studying the biology of the male germline stem cell and its microenvironment, the stem cell …