Galectins are a family of proteins that bind to specific glycans thereby deciphering the
information captured within the glycome. In the last two decades, several galectin family …

Galectins are a family of carbohydrate-binding proteins with an affinity for β-galactosides.
Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and …

Galectin-3 is unique among the galectin family of animal lectins in its biological activities and
structure. Most members of the galectin family including galectin-1 possess apoptotic …

Despite the existence of tumor-specific immune cells, most tumors have devised strategies
to avoid immune attack. We demonstrate here that galectin-1 (Gal-1), a negative regulator of …

Only a subset of patients with newly diagnosed glioblastoma (GBM) exhibit a response to
standard therapy. To date, a biomarker panel with predictive power to distinguish treatment …

Purpose The present review aims to emphasize that malignant gliomas are characterized by
the diffuse invasion of distant brain tissue by a myriad of single migrating cells that exhibit …

Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-
galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues …

Glioblastoma is among the most aggressive forms of cancers, with a median survival of just
15–20 months for patients despite maximum clinical intervention. The majority of …

Depending on the cellular context, Ras can activate characteristic effectors by mechanisms
still poorly understood. Promotion by galectin-1 of Ras activation of Raf-1 but not of …

The galectins are a family of proteins that are distributed widely in all living organisms. All of
them share galactose-specificity. At present, 14 members of the family are characterized in …