Despite the widespread assumption that racial differences in stress exist and that stress is a
key mediator linking racial status to poor health, relatively few studies have explicitly …

Importance Many studies have demonstrated an association between early-life adversity
(ELA) and executive functioning in children and adolescents. However, the aggregate …

Maltreatment during childhood is a major risk factor for anxiety and depression, which are
major public health problems. However, the underlying brain mechanism linking …

Early life stress–including experience of child maltreatment, neglect, separation from or loss
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …

A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …

BACKGROUND: This study examines the prevalence, correlates, and psychiatric disorders
of adults with history of child sexual abuse (CSA). METHODS: Data were derived from a …

For more than a century, research on psychopathology has focused on categorical
diagnoses. Although this work has produced major discoveries, growing evidence points to …

Disrupted operations of the reward circuit underlie major emotional disorders, including
depression, which commonly arise following early life stress/adversity (ELA). However, how …

BackgroundChildhood adversity (CA) is associated with adult mental disorders, but the
mechanisms underlying this association remain inadequately understood. Stress …

Rationale Genetic and environmental influences on the development of alcohol and drug
dependence are equally important. Exposure to early life stress, that is unfortunately …