The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence

HE Barker, JTE Paget, AA Khan… - Nature Reviews Cancer, 2015 - nature.com
Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …

Combinatorial therapy in tumor microenvironment: where do we stand?

S Kumari, D Advani, S Sharma, RK Ambasta… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …

[HTML][HTML] Combined radiotherapy and anti–PD-L1 antibody synergistically enhances antitumor effect in non–small cell lung cancer

X Gong, X Li, T Jiang, H Xie, Z Zhu, F Zhou… - Journal of Thoracic …, 2017 - Elsevier
Introduction Immune escape frequently occurs and restricts the durability of the antitumor
immune response to radiotherapy. Programmed death 1 (PD-1) and programmed death …

Bacteria and bacterial derivatives as drug carriers for cancer therapy

Z Cao, J Liu - Journal of Controlled Release, 2020 - Elsevier
The application of bacteria and bacteria-derived membrane vesicles (MVs) has promising
potential to make a great impact on the development of controllable targeted drug delivery …

[HTML][HTML] Clinical development of new drug–radiotherapy combinations

RA Sharma, R Plummer, JK Stock… - Nature reviews Clinical …, 2016 - nature.com
In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …

Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment

Y Muroyama, TR Nirschl, CM Kochel… - Cancer immunology …, 2017 - AACR
Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects
of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor …

[HTML][HTML] Targeting growth hormone function: strategies and therapeutic applications

M Lu, JU Flanagan, RJ Langley, MP Hay… - Signal transduction and …, 2019 - nature.com
Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …

TGF-beta signaling in cancer radiotherapy

J Wang, Z Xu, Z Wang, G Du, L Lun - Cytokine, 2021 - Elsevier
Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation
and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early …

Application of capsaicin as a potential new therapeutic drug in human cancers

S Zhang, D Wang, J Huang, Y Hu… - Journal of clinical …, 2020 - Wiley Online Library
What is known and objective Capsaicin, the major active ingredient of chili pepper, may play
a “dual role” in tumourigenesis, acting as a carcinogen or as a cancer preventive agent. The …

Enhanced radiosensitization by gold nanoparticles with acid‐triggered aggregation in cancer radiotherapy

Y Zhang, F Huang, C Ren, J Liu, L Yang… - Advanced …, 2019 - Wiley Online Library
An ideal radiosensitizer holding an enhanced tumor retention can play an incredible role in
enhancing tumor radiotherapy. Herein, a strategy of acid‐triggered aggregation of small …