Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is
largely derived from mitochondria–unique multifunctional organelles with their own genome …

Glucocorticoids are steroid hormones that regulate multiple aspects of glucose homeostasis.
Glucocorticoids promote gluconeogenesis in liver, whereas in skeletal muscle and white …

Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty
acids) oxidation based on nutrient availability. The ability to alter substrate oxidation in …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate
decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

During sepsis, the importance of alterations in cell metabolism is underappreciated. The
cellular metabolism, which has a variable metabolic profile in different cells and disease …

Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is
associated with the development of obesity and metabolic syndrome. However, it is not …

Glucocorticoids (GCs) exert key metabolic influences on skeletal muscle. GCs increase
protein degradation and decrease protein synthesis. The released amino acids are …

Background/Aims: Systemic hyperlipidemia and intracellular lipid accumulation induced by
chronic high fat diet (HFD) leads to enhanced fatty acid oxidation (FAO) and ketogenesis …