Role of silymarin in cancer treatment: facts, hypotheses, and questions

T Koltai, L Fliegel - Journal of Evidence-Based Integrative …, 2022 - journals.sagepub.com
The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Milk Thistle (Silybum Marianum L.) as a Novel Multipurpose Crop for Agriculture in Marginal Environments: A Review

R Marceddu, L Dinolfo, A Carrubba, M Sarno… - Agronomy, 2022 - mdpi.com
Milk thistle (Silybum marianum (L.) Gaertn.) is a versatile crop that has adapted to the
broadly different soil and environmental conditions throughout all continents. To date, the …

[HTML][HTML] Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

M Koushki, RF Yekta, N Amiri-Dashatan - Journal of Functional Foods, 2023 - Elsevier
Cancer is identified as second leading causes of death and imposes a significant
psychological and economic burden on societies. Due to its high prevalence, and a main …

[HTML][HTML] Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations

Y Wang, AJ Yuan, YJ Wu, LM Wu, L Zhang - Journal of Functional Foods, 2023 - Elsevier
Silymarin, a milk thistle extract, has anti-inflammatory, immunomodulatory, anti-lipid
peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits …

In vitro-in vivo correlation in nanocarriers: From protein corona to therapeutic implications

TG Agnihotri, A Alexander, M Agrawal… - Journal of Controlled …, 2023 - Elsevier
Understanding and establishing a link between the physicochemical characteristics of
nanoparticles (NPs) and their biological interactions poses to be a great challenge in the …

Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review

T Koltai, SJ Reshkin, TMA Carvalho, D Di Molfetta… - Cancers, 2022 - mdpi.com
Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Silymarin, an antioxidant flavonoid, protects the liver from the toxicity of the anticancer drug paclitaxel

FM Gür, S Bilgiç - Tissue and Cell, 2023 - Elsevier
One of the biggest factors that negatively affect the cancer treatment plan is the toxic effects
of chemotherapeutics on non-target cells and tissues. This information prompted us to …

[HTML][HTML] The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and …

V Musazadeh, A Karimi, J Jafarzadeh, S Sanaie… - Biomedicine & …, 2022 - Elsevier
The proceeding pandemic of coronavirus disease 2019 is the latest global challenge. Like
most other infectious diseases, inflammation, oxidative stress, and immune system …

Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis

X Duan, X Yu, Z Li - Bioengineered, 2022 - Taylor & Francis
Gastric cancer (GC) is a tumor with high incidence and lack of early diagnostic markers. The
aim of this study was to explore novel regulatory circular RNAs (circRNAs) in GC and their …

Immunoprotective effect of silybin through blocking p53-driven caspase-9-Apaf-1-Cyt c complex formation and immune dysfunction after difenoconazole exposure in …

E Pan, Y Xin, X Li, K Ping, X Li, Y Sun, X Xu… - … Science and Pollution …, 2024 - Springer
As a broad-spectrum and efficient triazole fungicide, difenoconazole is widely used, which
not only pollutes the environment but also exerts toxic effects on non-target organisms. The …