Role of silymarin in cancer treatment: facts, hypotheses, and questions
The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …
Milk Thistle (Silybum Marianum L.) as a Novel Multipurpose Crop for Agriculture in Marginal Environments: A Review
Milk thistle (Silybum marianum (L.) Gaertn.) is a versatile crop that has adapted to the
broadly different soil and environmental conditions throughout all continents. To date, the …
broadly different soil and environmental conditions throughout all continents. To date, the …
[HTML][HTML] Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
Cancer is identified as second leading causes of death and imposes a significant
psychological and economic burden on societies. Due to its high prevalence, and a main …
psychological and economic burden on societies. Due to its high prevalence, and a main …
[HTML][HTML] Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
Y Wang, AJ Yuan, YJ Wu, LM Wu, L Zhang - Journal of Functional Foods, 2023 - Elsevier
Silymarin, a milk thistle extract, has anti-inflammatory, immunomodulatory, anti-lipid
peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits …
peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits …
In vitro-in vivo correlation in nanocarriers: From protein corona to therapeutic implications
Understanding and establishing a link between the physicochemical characteristics of
nanoparticles (NPs) and their biological interactions poses to be a great challenge in the …
nanoparticles (NPs) and their biological interactions poses to be a great challenge in the …
Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review
T Koltai, SJ Reshkin, TMA Carvalho, D Di Molfetta… - Cancers, 2022 - mdpi.com
Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …
Silymarin, an antioxidant flavonoid, protects the liver from the toxicity of the anticancer drug paclitaxel
One of the biggest factors that negatively affect the cancer treatment plan is the toxic effects
of chemotherapeutics on non-target cells and tissues. This information prompted us to …
of chemotherapeutics on non-target cells and tissues. This information prompted us to …
[HTML][HTML] The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and …
The proceeding pandemic of coronavirus disease 2019 is the latest global challenge. Like
most other infectious diseases, inflammation, oxidative stress, and immune system …
most other infectious diseases, inflammation, oxidative stress, and immune system …
Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis
X Duan, X Yu, Z Li - Bioengineered, 2022 - Taylor & Francis
Gastric cancer (GC) is a tumor with high incidence and lack of early diagnostic markers. The
aim of this study was to explore novel regulatory circular RNAs (circRNAs) in GC and their …
aim of this study was to explore novel regulatory circular RNAs (circRNAs) in GC and their …
Immunoprotective effect of silybin through blocking p53-driven caspase-9-Apaf-1-Cyt c complex formation and immune dysfunction after difenoconazole exposure in …
E Pan, Y Xin, X Li, K Ping, X Li, Y Sun, X Xu… - … Science and Pollution …, 2024 - Springer
As a broad-spectrum and efficient triazole fungicide, difenoconazole is widely used, which
not only pollutes the environment but also exerts toxic effects on non-target organisms. The …
not only pollutes the environment but also exerts toxic effects on non-target organisms. The …