The covalent immobilisation of enzymes generally involves the use of highly reactive
crosslinkers, such as glutaraldehyde, to couple enzyme molecules to each other or to …

Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …

Site-selective protein modification is of significant interest in chemical biology research, with
lysine residues representing a particularly challenging target. Whilst lysines are popular for …

Interest in self-immolative chemistry has grown over the past decade with more research
groups harnessing the versatility to control the release of a compound from a larger …

In the last decade, the interest in ferritin-based vaccines has been increasing due to their
safety and immunogenicity. Candidates against a wide range of pathogens are now on …

Melanins are highly conjugated biopolymer pigments that provide photoprotection in a wide
array of organisms, from bacteria to humans. The rate-limiting step in melanin biosynthesis …

A new enzymatic method is reported for constructing protein-and DNA-AuNP conjugates.
The strategy relies on the initial functionalization of AuNPs with phenols, followed by …

Protein bioconjugation is an increasingly important field of research, with wide-ranging
applications in areas such as therapeutics and biomaterials. Traditional cysteine and lysine …

Click chemistry has been established rapidly as one of the most valuable methods for the
chemical transformation of complex molecules. Due to the rapid rates, clean conversions to …

We have developed a novel visible‐light‐catalyzed bioconjugation reaction, PhotoCLIC, that
enables chemoselective attachment of diverse aromatic amine reagents onto a site …