[HTML][HTML] Rip it, stitch it, click it: A Chemist's guide to VLP manipulation
Viruses are some of nature's most ubiquitous self-assembled molecular containers.
Evolutionary pressures have created some incredibly robust, thermally, and enzymatically …
Evolutionary pressures have created some incredibly robust, thermally, and enzymatically …
[HTML][HTML] Intelligent nanotherapeutic strategies for the delivery of CRISPR system
C Chen, W Zhong, S Du, Y Li, Y Zeng, K Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
CRISPR, as an emerging gene editing technology, has been widely used in multiple fields
due to its convenient operation, less cost, high efficiency and precision. This robust and …
due to its convenient operation, less cost, high efficiency and precision. This robust and …
Single‐Step N‐Terminal Modification of Proteins via a Bio‐Inspired Copper (II)‐Mediated Aldol Reaction
K Hanaya, K Yamoto, K Taguchi… - … A European Journal, 2022 - Wiley Online Library
The chemical modification of proteins is an effective technique for manipulating the
properties and functions of proteins, and for creating protein‐based materials. The N …
properties and functions of proteins, and for creating protein‐based materials. The N …
Fabricating Multiphasic Angiogenic Scaffolds Using Amyloid/Roxadustat-Assisted High-Temperature Protein Printing
M Akbarian, M Kianpour, L Tayebi - ACS Applied Materials & …, 2024 - ACS Publications
Repairing multiphasic defects is cumbersome. This study presents new soft and hard
scaffold designs aimed at facilitating the regeneration of multiphasic defects by enhancing …
scaffold designs aimed at facilitating the regeneration of multiphasic defects by enhancing …
[HTML][HTML] Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy
Protein-based conjugates have been extensively utilized in various biotechnological and
therapeutic applications. In order to prepare homogeneous conjugates, site-specific …
therapeutic applications. In order to prepare homogeneous conjugates, site-specific …
[HTML][HTML] Designed protein multimerization and polymerization for functionalization of proteins
D Permana, HE Putra, D Djaenudin - Biotechnology letters, 2022 - Springer
Multimeric and polymeric proteins are large biomacromolecules consisting of multiple
protein molecules as their monomeric units, connected through covalent or non-covalent …
protein molecules as their monomeric units, connected through covalent or non-covalent …
Total Synthesis of (S)-Cularine via Nucleophilic Substitution on a Catechol
Catechols are part of many essential chemicals and are valuable, typically nucleophilic
intermediates used in synthesis. Here we describe an unexpected transformation in which …
intermediates used in synthesis. Here we describe an unexpected transformation in which …
Molecular display on protein nanocompartments: design strategies and systems applications
TN Szyszka, EN Jenner, N Tasneem… - …, 2022 - Wiley Online Library
The design of biomimetic systems in the laboratory is a long‐sought goal for systems
chemists and synthetic biologists alike. Fundamental to this design is the generation of self …
chemists and synthetic biologists alike. Fundamental to this design is the generation of self …
Bis‐ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi‐Functional Protein‐and Antibody‐Drug‐Conjugates
Bis‐ethynylphosphonamidates allow for a simple chemoselective addition of two thiol‐
containing modules in a row. We describe four such bis‐electrophiles that carry different …
containing modules in a row. We describe four such bis‐electrophiles that carry different …
A Bioinspired Synthesis of 1,4-Benzothiazines by Selective Addition of Sulfur Nucleophiles to ortho-Quinones
MW Halloran, E Li, KVN Esguerra… - The Journal of Organic …, 2023 - ACS Publications
Herein, we report a bioinspired approach to the synthesis of 1, 4-benzothiazines by drawing
inspiration from the biosynthesis of pheomelanin pigments (pheomelanogenesis). In this …
inspiration from the biosynthesis of pheomelanin pigments (pheomelanogenesis). In this …