[HTML][HTML] Rip it, stitch it, click it: A Chemist's guide to VLP manipulation

YH Wijesundara, FC Herbert, S Kumari, T Howlett… - Virology, 2022 - Elsevier
Viruses are some of nature's most ubiquitous self-assembled molecular containers.
Evolutionary pressures have created some incredibly robust, thermally, and enzymatically …

[HTML][HTML] Intelligent nanotherapeutic strategies for the delivery of CRISPR system

C Chen, W Zhong, S Du, Y Li, Y Zeng, K Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
CRISPR, as an emerging gene editing technology, has been widely used in multiple fields
due to its convenient operation, less cost, high efficiency and precision. This robust and …

Single‐Step N‐Terminal Modification of Proteins via a Bio‐Inspired Copper (II)‐Mediated Aldol Reaction

K Hanaya, K Yamoto, K Taguchi… - … A European Journal, 2022 - Wiley Online Library
The chemical modification of proteins is an effective technique for manipulating the
properties and functions of proteins, and for creating protein‐based materials. The N …

Fabricating Multiphasic Angiogenic Scaffolds Using Amyloid/Roxadustat-Assisted High-Temperature Protein Printing

M Akbarian, M Kianpour, L Tayebi - ACS Applied Materials & …, 2024 - ACS Publications
Repairing multiphasic defects is cumbersome. This study presents new soft and hard
scaffold designs aimed at facilitating the regeneration of multiphasic defects by enhancing …

[HTML][HTML] Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy

Y Zhang, Y Wang, S Uslu… - International journal of …, 2022 - mdpi.com
Protein-based conjugates have been extensively utilized in various biotechnological and
therapeutic applications. In order to prepare homogeneous conjugates, site-specific …

[HTML][HTML] Designed protein multimerization and polymerization for functionalization of proteins

D Permana, HE Putra, D Djaenudin - Biotechnology letters, 2022 - Springer
Multimeric and polymeric proteins are large biomacromolecules consisting of multiple
protein molecules as their monomeric units, connected through covalent or non-covalent …

Total Synthesis of (S)-Cularine via Nucleophilic Substitution on a Catechol

Z Huang, X Ji, JP Lumb - Organic Letters, 2020 - ACS Publications
Catechols are part of many essential chemicals and are valuable, typically nucleophilic
intermediates used in synthesis. Here we describe an unexpected transformation in which …

Molecular display on protein nanocompartments: design strategies and systems applications

TN Szyszka, EN Jenner, N Tasneem… - …, 2022 - Wiley Online Library
The design of biomimetic systems in the laboratory is a long‐sought goal for systems
chemists and synthetic biologists alike. Fundamental to this design is the generation of self …

Bis‐ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi‐Functional Protein‐and Antibody‐Drug‐Conjugates

MA Kasper, L Lassak, AM Vogl, I Mai… - European Journal of …, 2022 - Wiley Online Library
Bis‐ethynylphosphonamidates allow for a simple chemoselective addition of two thiol‐
containing modules in a row. We describe four such bis‐electrophiles that carry different …

A Bioinspired Synthesis of 1,4-Benzothiazines by Selective Addition of Sulfur Nucleophiles to ortho-Quinones

MW Halloran, E Li, KVN Esguerra… - The Journal of Organic …, 2023 - ACS Publications
Herein, we report a bioinspired approach to the synthesis of 1, 4-benzothiazines by drawing
inspiration from the biosynthesis of pheomelanin pigments (pheomelanogenesis). In this …