Interindividual variability in response to drugs used in anesthesia has long been considered
the rule, not the exception. It is important to mention that in anesthesiology, the variability in …

HSK3486, a central nervous system inhibitor, has demonstrated superior anesthetic
properties in comparison with propofol. Owing to the high liver extraction ratio of HSK3486 …

Background Propofol is a widely used intravenous hypnotic. Dosing is based mostly on
weight, with great interindividual variation in consumption. Suggested factors affecting …

In this review, we aim to discuss the use and effect of five different drugs used in the
induction of anesthesia in cancer patients. Propofol, fentanyl, rocuronium, sugammadex …

Purpose To explore the effect of gene polymorphisms of propofol GABAA receptor and
metabolic enzyme on drug susceptibility during the induction period of general anesthesia …

Responses to sedatives, analgesics and muscle relaxants vary among patients under
general anesthesia, which could be ascribed to the disparities of clinical characteristics and …

Purpose: Etomidate is widely used in general anesthesia and sedation, and significant
individual differences are observed during anesthesia induction. This study aimed to explore …

Management of severe traumatic brain injury (sTBI) typically involves the use of sedation,
which inherently results in benefits and risks. The cytochrome P450 enzyme CYP2B6 is …

Management of critically ill patients requires simultaneous administration of many
medications. Treatment for patient comorbidities may lead to drug–drug interactions which …

Background: Propofol is an intravenous agent for clinical anesthesia. As the influence of the
hypobaric-hypoxic environment (Qinghai-Tibetan region, altitude: 2800-4300 m, PaO2: 15.1 …