Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments

MA Elafros, H Andersen, DL Bennett… - The Lancet …, 2022 - thelancet.com
Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …

New perspectives in diabetic neuropathy

SA Eid, AE Rumora, B Beirowski, DL Bennett, J Hur… - Neuron, 2023 - cell.com
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan—2022 update

L Blonde, GE Umpierrez, SS Reddy, JB McGill… - Endocrine Practice, 2022 - Elsevier
Objective The objective of this clinical practice guideline is to provide updated and new
evidence-based recommendations for the comprehensive care of persons with diabetes …

Diagnosis and treatment of painful diabetic peripheral neuropathy

R Pop-Busui, L Ang, AJM Boulton, EL Feldman… - 2022 - Am Diabetes Assoc
Diabetic neuropathies are the most common chronic complications of diabetes, with an
estimated lifetime prevalence exceeding 50% in people with diabetes. Among various forms …

[PDF][PDF] ISPAD clinical practice consensus guidelines 2022: microvascular and macrovascular complications in children and adolescents with diabetes

P Bjornstad, A Dart, KC Donaghue, A Dost… - 2022 - deepblue.lib.umich.edu
The long-term vascular complications of diabetes include diabetic kidney disease (DKD),
retinopathy, neuropathy, and macrovascular disease. The outcomes are:• kidney failure and …

Spectrum of diabetic neuropathy: new insights in diagnosis and treatment

BR Dillon, L Ang, R Pop-Busui - Annual Review of Medicine, 2024 - annualreviews.org
Diabetic neuropathy is a highly prevalent complication of diabetes. It consists of a broad
range of neuropathic conditions, such as distal symmetric polyneuropathy and various forms …

Interactions between the microbiota and enteric nervous system during gut-brain disorders

S Fried, E Wemelle, PD Cani, C Knauf - Neuropharmacology, 2021 - Elsevier
For the last 20 years, researchers have focused their intention on the impact of gut
microbiota in healthy and pathological conditions. This year (2021), more than 25,000 …

[HTML][HTML] Optimizing and accelerating the development of precision pain treatments for chronic pain: IMMPACT review and recommendations

RR Edwards, KL Schreiber, RH Dworkin, DC Turk… - The journal of pain, 2023 - Elsevier
Large variability in the individual response to even the most-efficacious pain treatments is
observed clinically, which has led to calls for a more personalized, tailored approach to …

Silencing P2X7R alleviates diabetic neuropathic pain involving TRPV1 via PKCε/P38MAPK/NF-κB signaling pathway in rats

L Chen, H Wang, J Xing, X Shi, H Huang… - International Journal of …, 2022 - mdpi.com
Transient receptor potential vanillic acid 1 (TRPV1) is an ion channel activated by heat and
inflammatory factors involved in the development of various types of pain. The P2X7 …

How inflammation dictates diabetic peripheral neuropathy: An enlightening review

Y Cheng, Y Chen, K Li, S Liu, C Pang… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Diabetic peripheral neuropathy (DPN) constitutes a debilitating complication
associated with diabetes. Although, the past decade has seen rapid developments in …